This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase mu 1] with antituberculosis drug-induced hepatotoxicity (ATDH). We also investigated the potential gene-gene and gene-environment interactions as well as their association with ATDH development in a population of hospitalized TB patients from Buenos Aires.

Chamorro, J., Castagnino, J., Aidar, O., Musella, R., Frías, A., Visca, M., et al. (2017). Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 27(10), 363-371 [10.1097/FPC.0000000000000300].

Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity

Perez, Alessandro;CARADONNA, Fabio;
2017

Abstract

This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase mu 1] with antituberculosis drug-induced hepatotoxicity (ATDH). We also investigated the potential gene-gene and gene-environment interactions as well as their association with ATDH development in a population of hospitalized TB patients from Buenos Aires.
Settore BIO/18 - Genetica
Chamorro, J., Castagnino, J., Aidar, O., Musella, R., Frías, A., Visca, M., et al. (2017). Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 27(10), 363-371 [10.1097/FPC.0000000000000300].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/241587
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