This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase mu 1] with antituberculosis drug-induced hepatotoxicity (ATDH). We also investigated the potential gene-gene and gene-environment interactions as well as their association with ATDH development in a population of hospitalized TB patients from Buenos Aires.
Chamorro, J., Castagnino, J., Aidar, O., Musella, R., Frías, A., Visca, M., et al. (2017). Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 27(10), 363-371 [10.1097/FPC.0000000000000300].
Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity
Perez, Alessandro;CARADONNA, Fabio;
2017-01-01
Abstract
This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase mu 1] with antituberculosis drug-induced hepatotoxicity (ATDH). We also investigated the potential gene-gene and gene-environment interactions as well as their association with ATDH development in a population of hospitalized TB patients from Buenos Aires.
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