Chromogranin A (CgA), one component of the granin family, represents the major soluble protein co-stored and co-released with catecholamines, within chromaffin cells secretory granules. It is considered a diagnostic and prognostic marker of several diseases, including a variety of tumours and cardiac heart failure. It also represents a precursor of biologically active fragments, generated after proteolytic cleavage at the level of the multiple pairs of dibasic sites which enrich its sequence.
TOTA B, QUINTIERI AM, DI FELICE V, CERRA MC (2007). New biological aspects of Chromogranin A-derived peptides: Focus on vasostatins. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART A, MOLECULAR & INTEGRATIVE PHYSIOLOGY, 147(1), 11-18 [10.1016/j.cbpa.2006.05.016].
New biological aspects of Chromogranin A-derived peptides: Focus on vasostatins
DI FELICE, Valentina;
2007-01-01
Abstract
Chromogranin A (CgA), one component of the granin family, represents the major soluble protein co-stored and co-released with catecholamines, within chromaffin cells secretory granules. It is considered a diagnostic and prognostic marker of several diseases, including a variety of tumours and cardiac heart failure. It also represents a precursor of biologically active fragments, generated after proteolytic cleavage at the level of the multiple pairs of dibasic sites which enrich its sequence.
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