Malignant pleural mesothelioma (MPM) is an aggressive tumor of the pleura with a poor prognosis. The most active first-line regimens are platinum compounds and pemetrexed. There is no standard second-line treatment in MPM. Advances in the understanding of tumor molecular biology have led to the development of several targeted treatments, which have been evaluated in clinical trials. Unfortunately none of the explored targeted treatments can currently be recommended as routine treatment in MPM. We reviewed the biological pathways involved in MPM, the clinical trials about targeted therapy, and possible related mechanisms of resistance. We suggest that specific genetic markers are needed as targets of selective therapy. By this way the selection of patients based on the molecular profile may facilitate a therapeutic strategy that allows the use of the most appropriate drug for each patient.

Bronte, G., Incorvaia, L., Rizzo, S., Passiglia, F., Galvano, A., Rizzo, F., et al. (2016). The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 107, 20-32 [10.1016/j.critrevonc.2016.08.011].

The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?

BRONTE, Giuseppe;INCORVAIA, Lorena;RIZZO, Sergio;PASSIGLIA, Francesco;GALVANO, Antonio;RIZZO, Fabio;Rolfo, CHRISTIAN DIEGO;FANALE, Daniele;LISTI', Angela;BAZAN, Viviana;RUSSO, Antonio
2016

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive tumor of the pleura with a poor prognosis. The most active first-line regimens are platinum compounds and pemetrexed. There is no standard second-line treatment in MPM. Advances in the understanding of tumor molecular biology have led to the development of several targeted treatments, which have been evaluated in clinical trials. Unfortunately none of the explored targeted treatments can currently be recommended as routine treatment in MPM. We reviewed the biological pathways involved in MPM, the clinical trials about targeted therapy, and possible related mechanisms of resistance. We suggest that specific genetic markers are needed as targets of selective therapy. By this way the selection of patients based on the molecular profile may facilitate a therapeutic strategy that allows the use of the most appropriate drug for each patient.
Settore MED/06 - Oncologia Medica
Bronte, G., Incorvaia, L., Rizzo, S., Passiglia, F., Galvano, A., Rizzo, F., et al. (2016). The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 107, 20-32 [10.1016/j.critrevonc.2016.08.011].
File in questo prodotto:
File Dimensione Formato  
The resistance related to targeted therapy in malignant pleural.pdf

Solo gestori archvio

Dimensione 1.87 MB
Formato Adobe PDF
1.87 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/237326
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 20
social impact