Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
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EnglishVgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.
Caccamo, N., Battistini, L., Bonneville, M., Poccia, F., Fournie', J., Meraviglia, S., et al. (2006). CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production. JOURNAL OF IMMUNOLOGY, 177, 5290-5295.
| Data di pubblicazione: | 2006 |
| Titolo: | CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production. |
| Autori: | |
| Citazione: | Caccamo, N., Battistini, L., Bonneville, M., Poccia, F., Fournie', J., Meraviglia, S., et al. (2006). CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production. JOURNAL OF IMMUNOLOGY, 177, 5290-5295. |
| Rivista: | |
| Abstract: | Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function. |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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