Background and Aims Galectin 3 (Gal 3) is a β-galactoside-binding lectin known to play a part in inflammation, adverse remodeling and fibrosis. Gal 3 seems to be linked to atherogenesis and Coronary Artery Disease (CAD), but less is known about the relationship between Gal 3 and acute myocardial infarction (AMI). The aim of the present study is to assess circulating levels of Gal 3 after AMI and to evaluate short-term changes of the biomarker within 5 days from the acute event. Methods Two hundred fifteen confirmed AMI patients (125 STEMI, M/F = 2.8; mean age: 65.4 ± 13.8 years) were enrolled in the present study; two blood samples were collected from each patient: first, within 1 h from admission to the Emergency Area (T1) and then upon discharge (T2). Results Kinetics of Gal 3 during AMI show that the marker boosts during the acute event (T1) and then decreases from baseline, being significantly lower at T2 (18 [14.2–25] vs. 16.8 [12.7–23.4]; p = 0.006). Gal 3 levels were correlated to hsTnI and eGFR on admission (r = 0.2; p <0.001 and r = −0.25; p <0.001, respectively). Linear regression analysis confirms an association between Gal 3 and ejection fraction (r2 = 0.037; p = 0.005). Conclusions Gal 3 is reasonably supposed to be a part of those mechanisms leading to formation, destabilization and rupture of plaque; however, the usefulness of Gal 3 as a biomarker in CAD/AMI is far from being elucidated.

Bivona, G., Bellia, C., Lo Sasso, B., Agnello, L., Scazzone, C., Novo, G., et al. (2016). Short-term Changes in Gal 3 Circulating Levels After Acute Myocardial Infarction. ARCHIVES OF MEDICAL RESEARCH, 47(7), 521-525 [10.1016/j.arcmed.2016.12.009].

Short-term Changes in Gal 3 Circulating Levels After Acute Myocardial Infarction

BIVONA, Giulia;BELLIA, Chiara;LO SASSO, Bruna;AGNELLO, Luisa;SCAZZONE, Concetta;NOVO, Giuseppina;CIACCIO, Marcello
2016-01-01

Abstract

Background and Aims Galectin 3 (Gal 3) is a β-galactoside-binding lectin known to play a part in inflammation, adverse remodeling and fibrosis. Gal 3 seems to be linked to atherogenesis and Coronary Artery Disease (CAD), but less is known about the relationship between Gal 3 and acute myocardial infarction (AMI). The aim of the present study is to assess circulating levels of Gal 3 after AMI and to evaluate short-term changes of the biomarker within 5 days from the acute event. Methods Two hundred fifteen confirmed AMI patients (125 STEMI, M/F = 2.8; mean age: 65.4 ± 13.8 years) were enrolled in the present study; two blood samples were collected from each patient: first, within 1 h from admission to the Emergency Area (T1) and then upon discharge (T2). Results Kinetics of Gal 3 during AMI show that the marker boosts during the acute event (T1) and then decreases from baseline, being significantly lower at T2 (18 [14.2–25] vs. 16.8 [12.7–23.4]; p = 0.006). Gal 3 levels were correlated to hsTnI and eGFR on admission (r = 0.2; p <0.001 and r = −0.25; p <0.001, respectively). Linear regression analysis confirms an association between Gal 3 and ejection fraction (r2 = 0.037; p = 0.005). Conclusions Gal 3 is reasonably supposed to be a part of those mechanisms leading to formation, destabilization and rupture of plaque; however, the usefulness of Gal 3 as a biomarker in CAD/AMI is far from being elucidated.
2016
Bivona, G., Bellia, C., Lo Sasso, B., Agnello, L., Scazzone, C., Novo, G., et al. (2016). Short-term Changes in Gal 3 Circulating Levels After Acute Myocardial Infarction. ARCHIVES OF MEDICAL RESEARCH, 47(7), 521-525 [10.1016/j.arcmed.2016.12.009].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/229036
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