Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.

Cappelli, A., Paolino, M., Grisci, G., Razzano, V., Giuliani, G., Donati, A., et al. (2016). Hyaluronan-coated polybenzofulvene brushes as biomimetic materials. POLYMER CHEMISTRY, 7(42), 6529-6544 [10.1039/c6py01644h].

Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

SCIALABBA, Cinzia;GIAMMONA, Gaetano;LICCIARDI, Mariano
2016-01-01

Abstract

Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.
2016
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Cappelli, A., Paolino, M., Grisci, G., Razzano, V., Giuliani, G., Donati, A., et al. (2016). Hyaluronan-coated polybenzofulvene brushes as biomimetic materials. POLYMER CHEMISTRY, 7(42), 6529-6544 [10.1039/c6py01644h].
File in questo prodotto:
File Dimensione Formato  
HA-PBF-PolChem-2016.pdf

Solo gestori archvio

Dimensione 3.35 MB
Formato Adobe PDF
3.35 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/225504
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 25
social impact