This paper describes aspects of the chemistry of 4’-substituted spiro [indole-1,3’-pyrazoles]. These compounds underwent substitution and/or elimination reactions to afford some new spiro- as well as biaryl derivatives of potential pharmaceutical relevance. Mechanistic considerations are discussed as well.
Maggio, B., Fontana, G., Raimondi, M.V., Raffa, D., Plescia, F., Ingarra, A.M., et al. (2017). The Reactivity of 4’-Substituted Spiro[Isoindole-1,3’-pyrazoles] Derivatives: Substitution/Elimination Reactions and Access to Biaryl Derivatives. HETEROCYCLES, 94(2), 241-254 [10.3987/COM-16-13543].
The Reactivity of 4’-Substituted Spiro[Isoindole-1,3’-pyrazoles] Derivatives: Substitution/Elimination Reactions and Access to Biaryl Derivatives
MAGGIO, Benedetta;FONTANA, Gianfranco;RAIMONDI, Maria Valeria;RAFFA, Demetrio;PLESCIA, Fabiana;INGARRA, Angela Maria;DAIDONE, Giuseppe
2017-01-01
Abstract
This paper describes aspects of the chemistry of 4’-substituted spiro [indole-1,3’-pyrazoles]. These compounds underwent substitution and/or elimination reactions to afford some new spiro- as well as biaryl derivatives of potential pharmaceutical relevance. Mechanistic considerations are discussed as well.
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