Cisplatin analogs, having cytotoxic activity higher than that exerted by cisplatin, have recently triggered considerable interest by the community. The cis-[PtCl2(DMSO)HL]·2DMSO, where HL = 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid, has shown a potent cytotoxic activity on HepG2 hepatocarcinoma cells, while under identical conditions, it did not affect normal immortalized human liver cells (Chang). In this work, the above complex has been incorporated into MCM41 mesoporous silica, pure and functionalized with amino group, which is considered one of the best host for a drug delivery system for carrying high dosages of a variety of drugs in their mesopores. Since the controlled release of an anticancer drug helps to maintain its therapeutic level for an extended time period while minimizing undesirable high peaks immediately following administration, the in vitro tests have been performed in order to obtain the corresponding drug release profile. The investigated system demonstrated to be an efficient system for pharmaceutic controlled release. A deepened characterization of the systems has been performed in order to known their structure and features and to speculate the mechanisms involved in the release.

Saladino, M.L., Rubino, S., Colomba, P., Girasolo, M.A., Chillura Martino, D.F., Demirbag, C., et al. (2016). Pt(II) complex @mesoporous silica: preparation, characterization and study of release. BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 6(6), 1621-1626.

Pt(II) complex @mesoporous silica: preparation, characterization and study of release

SALADINO, Maria Luisa;RUBINO, Simona;GIRASOLO, Maria Assunta;CHILLURA MARTINO, Delia Francesca;CAPONETTI, Eugenio
2016-01-01

Abstract

Cisplatin analogs, having cytotoxic activity higher than that exerted by cisplatin, have recently triggered considerable interest by the community. The cis-[PtCl2(DMSO)HL]·2DMSO, where HL = 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid, has shown a potent cytotoxic activity on HepG2 hepatocarcinoma cells, while under identical conditions, it did not affect normal immortalized human liver cells (Chang). In this work, the above complex has been incorporated into MCM41 mesoporous silica, pure and functionalized with amino group, which is considered one of the best host for a drug delivery system for carrying high dosages of a variety of drugs in their mesopores. Since the controlled release of an anticancer drug helps to maintain its therapeutic level for an extended time period while minimizing undesirable high peaks immediately following administration, the in vitro tests have been performed in order to obtain the corresponding drug release profile. The investigated system demonstrated to be an efficient system for pharmaceutic controlled release. A deepened characterization of the systems has been performed in order to known their structure and features and to speculate the mechanisms involved in the release.
2016
Settore CHIM/03 - Chimica Generale E Inorganica
Saladino, M.L., Rubino, S., Colomba, P., Girasolo, M.A., Chillura Martino, D.F., Demirbag, C., et al. (2016). Pt(II) complex @mesoporous silica: preparation, characterization and study of release. BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 6(6), 1621-1626.
File in questo prodotto:
File Dimensione Formato  
O3_metioco (1) (1).pdf

accesso aperto

Descrizione: Articolo principale
Dimensione 302.26 kB
Formato Adobe PDF
302.26 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/221930
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 8
social impact