The conversion of cells with an epithelial phenotype into cells with a mesenchymal phenotype, referred to as epithelial-mesenchymal transition, is a critical process for embryonic development that also occurs in adult life, particularly during tumour progression. Tumour cells undergoing epithelial-mesenchymal transition acquire the capacity to disarm the body's antitumour defences, resist apoptosis and anticancer drugs, disseminate throughout the organism, and act as a reservoir that replenishes and expands the tumour cell population. Epithelial-mesenchymal transition is therefore becoming a target of prime interest for anticancer therapy. Here, we discuss the screening and classification of compounds that affect epithelial-mesenchymal transition, highlight some compounds of particular interest, and address issues related to their clinical application.

Marcucci, F., Stassi, G., & De Maria, R. (2016). Epithelial-mesenchymal transition: A new target in anticancer drug discovery. NATURE REVIEWS DRUG DISCOVERY, 15(5), 311-325 [10.1038/nrd.2015.13].

Epithelial-mesenchymal transition: A new target in anticancer drug discovery

STASSI, Giorgio;
2016

Abstract

The conversion of cells with an epithelial phenotype into cells with a mesenchymal phenotype, referred to as epithelial-mesenchymal transition, is a critical process for embryonic development that also occurs in adult life, particularly during tumour progression. Tumour cells undergoing epithelial-mesenchymal transition acquire the capacity to disarm the body's antitumour defences, resist apoptosis and anticancer drugs, disseminate throughout the organism, and act as a reservoir that replenishes and expands the tumour cell population. Epithelial-mesenchymal transition is therefore becoming a target of prime interest for anticancer therapy. Here, we discuss the screening and classification of compounds that affect epithelial-mesenchymal transition, highlight some compounds of particular interest, and address issues related to their clinical application.
Marcucci, F., Stassi, G., & De Maria, R. (2016). Epithelial-mesenchymal transition: A new target in anticancer drug discovery. NATURE REVIEWS DRUG DISCOVERY, 15(5), 311-325 [10.1038/nrd.2015.13].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/220265
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