AIM: Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new 'nano-into-micro' approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier. METHODS: Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus. RESULTS & DISCUSSION: MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release. MPs resulted to be effective in Pseudomonas aeruginosa infections if compared with free tobramycin. CONCLUSION: MPs resulted to be a formulation of higher efficacy, with potential positive implications, as lower required dose, administration frequency, side effects and antibiotic resistance problems.

Craparo, E.F., Porsio, B., Schillaci, D., Cusimano, M., Spigolon, D., Giammona, G., et al. (2017). Polyanion-tobramycin nanocomplexes into functional microparticles for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. NANOMEDICINE, 12(1), 25-42 [10.2217/nnm-2016-0262].

Polyanion-tobramycin nanocomplexes into functional microparticles for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

CRAPARO, Emanuela Fabiola;Porsio, Barbara;SCHILLACI, Domenico;CUSIMANO, Maria Grazia;Spigolon, Dario;GIAMMONA, Gaetano;CAVALLARO, Gennara
2017-01-01

Abstract

AIM: Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new 'nano-into-micro' approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier. METHODS: Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus. RESULTS & DISCUSSION: MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release. MPs resulted to be effective in Pseudomonas aeruginosa infections if compared with free tobramycin. CONCLUSION: MPs resulted to be a formulation of higher efficacy, with potential positive implications, as lower required dose, administration frequency, side effects and antibiotic resistance problems.
2017
Craparo, E.F., Porsio, B., Schillaci, D., Cusimano, M., Spigolon, D., Giammona, G., et al. (2017). Polyanion-tobramycin nanocomplexes into functional microparticles for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. NANOMEDICINE, 12(1), 25-42 [10.2217/nnm-2016-0262].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/219770
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