Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010

Colafigli, M.; Torti, C.; Trecarichi, E.; Albini, L.; Rosi, A.; Micheli, V.; Manca, N.; Penco, G.; Bruzzone, B.; Punzi, G.; Corsi, P.; Parruti, G.; Bagnarelli, P.; Monno, L.; Gonnelli, A.; Cauda, R.; Di Giambenedetto, S.; Mancuso, S.

doi:10.1111/j.1469-0691.2012.03847.x

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Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.

Data di pubblicazione:	2012
Titolo:	Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010
Autori:	Colafigli, M Torti, C Trecarichi, E Albini, L Rosi, A Micheli, V Manca, N Penco, G Bruzzone, B Punzi, G Corsi, P Parruti, G Bagnarelli, P Monno, L Gonnelli, A Cauda, R Di Giambenedetto, S MANCUSO, Salvatrice mostra contributor esterni nascondi contributor esterni
Citazione:	Colafigli, M., Torti, C., Trecarichi, E., Albini, L., Rosi, A., Micheli, V., et al. (2012). Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. CLINICAL MICROBIOLOGY AND INFECTION, 18(8), E299-E304.
Rivista:	CLINICAL MICROBIOLOGY AND INFECTION
Digital Object Identifier (DOI):	10.1111/j.1469-0691.2012.03847.x
Abstract:	Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
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