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EnglishPrevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
Colafigli, M., Torti, C., Trecarichi, E., Albini, L., Rosi, A., Micheli, V., et al. (2012). Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. CLINICAL MICROBIOLOGY AND INFECTION, 18(8), E299-E304.
| Data di pubblicazione: | 2012 |
| Titolo: | Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010 |
| Autori: | |
| Citazione: | Colafigli, M., Torti, C., Trecarichi, E., Albini, L., Rosi, A., Micheli, V., et al. (2012). Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010. CLINICAL MICROBIOLOGY AND INFECTION, 18(8), E299-E304. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1469-0691.2012.03847.x |
| Abstract: | Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases. |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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