A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of blaKPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the blaKPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of blaKPC-3::Tn4401a caused by intramolecular transposition events were detected in the plasmid.

Fortini, D., Villa, L., Feudi, C., Pires, J., Bonura, C., Mammina, C., et al. (2016). Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(1), 646-649 [10.1128/AAC.01886-15].

Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy

BONURA, Celestino;MAMMINA, Caterina;
2016-01-01

Abstract

A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of blaKPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the blaKPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of blaKPC-3::Tn4401a caused by intramolecular transposition events were detected in the plasmid.
Settore MED/07 - Microbiologia E Microbiologia Clinica
Settore MED/42 - Igiene Generale E Applicata
http://aac.asm.org/content/60/1/646.full.pdf+html
Fortini, D., Villa, L., Feudi, C., Pires, J., Bonura, C., Mammina, C., et al. (2016). Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(1), 646-649 [10.1128/AAC.01886-15].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/210016
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