Synapsin I is a neuron-specific protein which is present in two isoforms, Ia and Ib. In the last few years this protein has been demonstrated to play a central role in the regulation of neurotransmitter release and synaptic plasticity. In this paper the developmental expression of this protein has been investigated in primary neuronal cultures from fetal rat brain cortices. The presence of thyroid hormone in the culture medium stimulates an early expression of the protein without exerting any effect at the level of mRNA transcription and accumulation. These observations implicate a T3-dependent regulation of this neuron-specific gene at the level of mRNA translation. © 1995 Plenum Publishing Corporation.
Di Liegro, I., Savettieri, G., Coppolino, M., Scaturro, M., Monte, M., Nastasi, T., et al. (1995). Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons. NEUROCHEMICAL RESEARCH, 20(2), 239-243 [10.1007/BF00970550].
Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons
DI LIEGRO, Italia;SAVETTIERI, Giovanni;SALEMI, Giuseppe;CESTELLI, Alessandro
1995-01-01
Abstract
Synapsin I is a neuron-specific protein which is present in two isoforms, Ia and Ib. In the last few years this protein has been demonstrated to play a central role in the regulation of neurotransmitter release and synaptic plasticity. In this paper the developmental expression of this protein has been investigated in primary neuronal cultures from fetal rat brain cortices. The presence of thyroid hormone in the culture medium stimulates an early expression of the protein without exerting any effect at the level of mRNA transcription and accumulation. These observations implicate a T3-dependent regulation of this neuron-specific gene at the level of mRNA translation. © 1995 Plenum Publishing Corporation.File | Dimensione | Formato | |
---|---|---|---|
1995 Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons.pdf
Solo gestori archvio
Descrizione: Articolo principale
Dimensione
848.39 kB
Formato
Adobe PDF
|
848.39 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.