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English[3H]Flunitrazepam (FNZ) binding to cortical neurons from fetal rat brain was investigated in vitro. The use of a synthetic medium specific for neurons made it possible to plot a developmental curve of3H-FNZ binding in an almost pure neuronal culture. Detectable specific binding was present in vitro at time 0 (that is, the 16th gestational day). A progressive increase of binding, due to an increment in the number of recognition sites, was observed on the subsequent days. The affinity of the specific binding sites to3H-FNZ was enhanced by the addition of exogenous GABA, whereas the density was not affected. © 1990 Plenum Publishing Corporation.
| Data di pubblicazione: | 1990 |
| Titolo: | Binding of flunitrazepam to differentiating neurons cultured in a chemically defined, hormone-supplemented medium |
| Autori: | |
| Citazione: | Savettieri, G., Guarneri, R., Salemi, G., LA BELLA, V., Ferraro, D., Scondotto, S., et al. (1990). Binding of flunitrazepam to differentiating neurons cultured in a chemically defined, hormone-supplemented medium. NEUROCHEMICAL RESEARCH, 15(8), 773-776. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/BF00968553 |
| Abstract: | [3H]Flunitrazepam (FNZ) binding to cortical neurons from fetal rat brain was investigated in vitro. The use of a synthetic medium specific for neurons made it possible to plot a developmental curve of3H-FNZ binding in an almost pure neuronal culture. Detectable specific binding was present in vitro at time 0 (that is, the 16th gestational day). A progressive increase of binding, due to an increment in the number of recognition sites, was observed on the subsequent days. The affinity of the specific binding sites to3H-FNZ was enhanced by the addition of exogenous GABA, whereas the density was not affected. © 1990 Plenum Publishing Corporation. |
| Settore Scientifico Disciplinare: | Settore MED/26 - Neurologia Settore BIO/19 - Microbiologia Generale |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| 1990 Binding of flunitrazepam to differentiating neurons cultured in a chemically defined, hormone-supplemented medium.pdf | Articolo principale | N/A | Administrator Richiedi una copia |
http://hdl.handle.net/10447/207501
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