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EnglishTo evaluate the presence of HIV-1 non-B subtypes in Sicily, we sequenced and genotyped HIV-1 PR and RT regions of the pol gene using plasma from 169 HIV-1-infected adult patients. All samples were obtained from a study of antiretroviral-associated resistance mutations resulting in virological failure during highly active antiretroviral therapy (HAART). Eight (4.7%) patients had the non-B HIV-1 subtype including some circulating recombinant forms (CRFs). All of these individuals acquired the infection by heterosexual transmission. The detection of HIV-1 non-B strains was significantly associated with younger age of HIV-1 acquisition. Our findings indicate, for the first time, the presence of HIV-1 non-B subtypes in Sicily in patients who experienced virological failure during HAART, and highlight the need for implementing a network for the epidemiological surveillance of HIV-1 subtypes in Southern Europe.
Tramuto, F., Vitale, F., Bonura, F., Romano, N., & Mancuso, S. (2004). DETECTION OF HIV TYPE 1 (HIV-1) NON-B SUBTYPES IN SICILY, ITALY. AIDS RESEARCH AND HUMAN RETROVIRUSES, 20(2)(2), 251-254.
| Data di pubblicazione: | 2004 |
| Titolo: | DETECTION OF HIV TYPE 1 (HIV-1) NON-B SUBTYPES IN SICILY, ITALY |
| Autori: | |
| Citazione: | Tramuto, F., Vitale, F., Bonura, F., Romano, N., & Mancuso, S. (2004). DETECTION OF HIV TYPE 1 (HIV-1) NON-B SUBTYPES IN SICILY, ITALY. AIDS RESEARCH AND HUMAN RETROVIRUSES, 20(2)(2), 251-254. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1089/088922204773004987 |
| Abstract: | To evaluate the presence of HIV-1 non-B subtypes in Sicily, we sequenced and genotyped HIV-1 PR and RT regions of the pol gene using plasma from 169 HIV-1-infected adult patients. All samples were obtained from a study of antiretroviral-associated resistance mutations resulting in virological failure during highly active antiretroviral therapy (HAART). Eight (4.7%) patients had the non-B HIV-1 subtype including some circulating recombinant forms (CRFs). All of these individuals acquired the infection by heterosexual transmission. The detection of HIV-1 non-B strains was significantly associated with younger age of HIV-1 acquisition. Our findings indicate, for the first time, the presence of HIV-1 non-B subtypes in Sicily in patients who experienced virological failure during HAART, and highlight the need for implementing a network for the epidemiological surveillance of HIV-1 subtypes in Southern Europe. |
| Settore Scientifico Disciplinare: | Settore MED/42 - Igiene Generale E Applicata |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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