To evaluate the presence of HIV-1 non-B subtypes in Sicily, we sequenced and genotyped HIV-1 PR and RT regions of the pol gene using plasma from 169 HIV-1-infected adult patients. All samples were obtained from a study of antiretroviral-associated resistance mutations resulting in virological failure during highly active antiretroviral therapy (HAART). Eight (4.7%) patients had the non-B HIV-1 subtype including some circulating recombinant forms (CRFs). All of these individuals acquired the infection by heterosexual transmission. The detection of HIV-1 non-B strains was significantly associated with younger age of HIV-1 acquisition. Our findings indicate, for the first time, the presence of HIV-1 non-B subtypes in Sicily in patients who experienced virological failure during HAART, and highlight the need for implementing a network for the epidemiological surveillance of HIV-1 subtypes in Southern Europe.

TRAMUTO F, VITALE F, BONURA F, ROMANO N, & MANCUSO S (2004). DETECTION OF HIV TYPE 1 (HIV-1) NON-B SUBTYPES IN SICILY, ITALY. AIDS RESEARCH AND HUMAN RETROVIRUSES, 20(2)(2), 251-254 [10.1089/088922204773004987].

DETECTION OF HIV TYPE 1 (HIV-1) NON-B SUBTYPES IN SICILY, ITALY

TRAMUTO, Fabio;VITALE, Francesco;ROMANO, Nino;MANCUSO, Salvatrice
2004

Abstract

To evaluate the presence of HIV-1 non-B subtypes in Sicily, we sequenced and genotyped HIV-1 PR and RT regions of the pol gene using plasma from 169 HIV-1-infected adult patients. All samples were obtained from a study of antiretroviral-associated resistance mutations resulting in virological failure during highly active antiretroviral therapy (HAART). Eight (4.7%) patients had the non-B HIV-1 subtype including some circulating recombinant forms (CRFs). All of these individuals acquired the infection by heterosexual transmission. The detection of HIV-1 non-B strains was significantly associated with younger age of HIV-1 acquisition. Our findings indicate, for the first time, the presence of HIV-1 non-B subtypes in Sicily in patients who experienced virological failure during HAART, and highlight the need for implementing a network for the epidemiological surveillance of HIV-1 subtypes in Southern Europe.
Settore MED/42 - Igiene Generale E Applicata
TRAMUTO F, VITALE F, BONURA F, ROMANO N, & MANCUSO S (2004). DETECTION OF HIV TYPE 1 (HIV-1) NON-B SUBTYPES IN SICILY, ITALY. AIDS RESEARCH AND HUMAN RETROVIRUSES, 20(2)(2), 251-254 [10.1089/088922204773004987].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/20601
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