Brain primary tumors are among the most diverse and complex human cancers, and they are normally classified on the basis of the cell-type and/or the grade of malignancy (the most malignant being glioblastoma multiforme (GBM), grade IV). Glioma cells are able to migrate throughout the brain and to stimulate angiogenesis, by inducing brain capillary endothelial cell proliferation. This in turn causes loss of tight junctions and fragility of the blood-brain barrier, which becomes leaky. As a consequence, the most serious clinical complication of glioblastoma is the vasogenic brain edema. Both glioma cell migration and edema have been correlated with modification of the expression/localization of different isoforms of aquaporins (AQPs), a family of water channels, some of which are also involved in the transport of other small molecules, such as glycerol and urea. In this review, we discuss relationships among expression/localization of AQPs and brain tumors/edema, also focusing on the possible role of these molecules as both diagnostic biomarkers of cancer progression, and therapeutic targets. Finally, we will discuss the possibility that AQPs, together with other cancer promoting factors, can be exchanged among brain cells via extracellular vesicles (EVs).

Maugeri, R., Schiera, G., Di Liegro, C.M., Fricano, A., Iacopino, D.G., & Di Liegro I. (2016). Aquaporins and Brain Tumors [10.3390/ijms17071029].

Aquaporins and Brain Tumors

Maugeri, R;SCHIERA, Gabriella;DI LIEGRO, Carlo Maria;Fricano, A;IACOPINO, Domenico;DI LIEGRO, Italia
2016-07-01

Abstract

Brain primary tumors are among the most diverse and complex human cancers, and they are normally classified on the basis of the cell-type and/or the grade of malignancy (the most malignant being glioblastoma multiforme (GBM), grade IV). Glioma cells are able to migrate throughout the brain and to stimulate angiogenesis, by inducing brain capillary endothelial cell proliferation. This in turn causes loss of tight junctions and fragility of the blood-brain barrier, which becomes leaky. As a consequence, the most serious clinical complication of glioblastoma is the vasogenic brain edema. Both glioma cell migration and edema have been correlated with modification of the expression/localization of different isoforms of aquaporins (AQPs), a family of water channels, some of which are also involved in the transport of other small molecules, such as glycerol and urea. In this review, we discuss relationships among expression/localization of AQPs and brain tumors/edema, also focusing on the possible role of these molecules as both diagnostic biomarkers of cancer progression, and therapeutic targets. Finally, we will discuss the possibility that AQPs, together with other cancer promoting factors, can be exchanged among brain cells via extracellular vesicles (EVs).
Settore BIO/10 - Biochimica
Settore BIO/06 - Anatomia Comparata E Citologia
Settore MED/27 - Neurochirurgia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964405/pdf/ijms-17-01029.pdf
Maugeri, R., Schiera, G., Di Liegro, C.M., Fricano, A., Iacopino, D.G., & Di Liegro I. (2016). Aquaporins and Brain Tumors [10.3390/ijms17071029].
File in questo prodotto:
File Dimensione Formato  
Aquaporins-and-brain-tumors2016International-Journal-of-Molecular-SciencesOpen-Access.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Versione Editoriale
Dimensione 722.83 kB
Formato Adobe PDF
722.83 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/204719
Citazioni
  • ???jsp.display-item.citation.pmc??? 31
  • Scopus 51
  • ???jsp.display-item.citation.isi??? 46
social impact