Objective: To investigate the relationship between haematological routine parameters and audiogram shapes in patients affected by sudden sensorineural hearing loss (SSNHL). Design: A retrospective study. All patients were divided into four groups according to the audiometric curve and mean values of haematological parameters (haemoglobin, white blood cell, neutrophils and lymphocytes relative count, platelet count, haematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen and neutrophil-to-lymphocite ratio) of each group were statistically compared. The prognostic role of blood profile and coagulation test was also examined. Study sample: A cohort of 183 SSNHL patients without comorbidities. Results: With a 48.78% of complete hearing recovery, individuals affected by upsloping hearing loss presented a better prognosis instead of flat (18.36%), downsloping (19.23%) and anacusis (2.45%) groups (p = 0.0001). The multivariate analysis of complete blood count values revealed lower mean percentage of lymphocytes (p = 0.041) and higher platelet levels (p = 0.015) in case of downsloping hearing loss; with the exception of fibrinogen (p = 0.041), none of the main haematological parameters studied resulted associated with poorer prognosis. Conclusions: Our work suggested a lack of association between haematological parameters and a defined audiometric picture in SSNHL patients; furthermore, only fibrinogen seems to influence the prognosis of this disease.

Salvago, P., Rizzo, S., Bianco, A., Martines, F. (2016). Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?. INTERNATIONAL JOURNAL OF AUDIOLOGY, 1-6 [10.1080/14992027.2016.1236418].

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

SALVAGO, Pietro;RIZZO, Serena;BIANCO, Antonino;MARTINES, Francesco
2016-01-01

Abstract

Objective: To investigate the relationship between haematological routine parameters and audiogram shapes in patients affected by sudden sensorineural hearing loss (SSNHL). Design: A retrospective study. All patients were divided into four groups according to the audiometric curve and mean values of haematological parameters (haemoglobin, white blood cell, neutrophils and lymphocytes relative count, platelet count, haematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen and neutrophil-to-lymphocite ratio) of each group were statistically compared. The prognostic role of blood profile and coagulation test was also examined. Study sample: A cohort of 183 SSNHL patients without comorbidities. Results: With a 48.78% of complete hearing recovery, individuals affected by upsloping hearing loss presented a better prognosis instead of flat (18.36%), downsloping (19.23%) and anacusis (2.45%) groups (p = 0.0001). The multivariate analysis of complete blood count values revealed lower mean percentage of lymphocytes (p = 0.041) and higher platelet levels (p = 0.015) in case of downsloping hearing loss; with the exception of fibrinogen (p = 0.041), none of the main haematological parameters studied resulted associated with poorer prognosis. Conclusions: Our work suggested a lack of association between haematological parameters and a defined audiometric picture in SSNHL patients; furthermore, only fibrinogen seems to influence the prognosis of this disease.
2016
Settore MED/31 - Otorinolaringoiatria
Settore MED/32 - Audiologia
Salvago, P., Rizzo, S., Bianco, A., Martines, F. (2016). Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?. INTERNATIONAL JOURNAL OF AUDIOLOGY, 1-6 [10.1080/14992027.2016.1236418].
File in questo prodotto:
File Dimensione Formato  
Sudden sensorineural hearing loss is there a relationship between routine haematological parameters and audiogram shapes.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 605.2 kB
Formato Adobe PDF
605.2 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/204460
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 21
social impact