The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the seeding site.
Chiodoni, C., Sangaletti, S., Tripodo, C., Colombo, M. (2015). The ins and outs of osteopontin. ONCOIMMUNOLOGY, 4(3), 1-2 [10.4161/2162402X.2014.978711].
The ins and outs of osteopontin
TRIPODO, Claudio;
2015-01-01
Abstract
The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the seeding site.
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