Purpose: In this work an antibiotic, ciprofloxacin (CFX), was incorporated into 2 different polymeric matrices, poly(lactic acid) (PLA) and polypropylene (PP), to provide them with antimicrobial properties. The influence of CFX content on release kinetics and on antimicrobial and mechanical properties was evaluated. Methods: CFX was incorporated into both the polymers by melt mixing. Results: The effect of CFX incorporation was found to strongly depend on which polymer matrix was used. In particular, the antimicrobial tests revealed that PLA samples containing CFX produced no inhibition zone and only a slight antibacterial activity was observed when the highest concentration of CFX was added to PLA. On the contrary, PP-based materials incorporating CFX, even those containing the smallest concentration of antibiotic, showed antimicrobial activity. These results were found to be in good agreement with the evaluation of the CFX release. Conclusions: The negative findings of PLA-based systems are attributed to degradation phenomena that occur during the melt processing, involving some interaction between PLA and CFX. A proposed reaction mechanism between CFX and PLA occurring in the melt is presented.

Scaffaro, R., Botta, L., Maio, A., Gallo, G. (2016). Incorporation of an antibiotic in poly(lactic acid) and polypropylene by melt processing. JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 14(3), e240-e247 [10.5301/jabfm.5000285].

Incorporation of an antibiotic in poly(lactic acid) and polypropylene by melt processing

SCAFFARO, Roberto;BOTTA, Luigi;MAIO, Andrea;GALLO, Giuseppe
2016-01-01

Abstract

Purpose: In this work an antibiotic, ciprofloxacin (CFX), was incorporated into 2 different polymeric matrices, poly(lactic acid) (PLA) and polypropylene (PP), to provide them with antimicrobial properties. The influence of CFX content on release kinetics and on antimicrobial and mechanical properties was evaluated. Methods: CFX was incorporated into both the polymers by melt mixing. Results: The effect of CFX incorporation was found to strongly depend on which polymer matrix was used. In particular, the antimicrobial tests revealed that PLA samples containing CFX produced no inhibition zone and only a slight antibacterial activity was observed when the highest concentration of CFX was added to PLA. On the contrary, PP-based materials incorporating CFX, even those containing the smallest concentration of antibiotic, showed antimicrobial activity. These results were found to be in good agreement with the evaluation of the CFX release. Conclusions: The negative findings of PLA-based systems are attributed to degradation phenomena that occur during the melt processing, involving some interaction between PLA and CFX. A proposed reaction mechanism between CFX and PLA occurring in the melt is presented.
2016
Scaffaro, R., Botta, L., Maio, A., Gallo, G. (2016). Incorporation of an antibiotic in poly(lactic acid) and polypropylene by melt processing. JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 14(3), e240-e247 [10.5301/jabfm.5000285].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/202034
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