In this work, we prepared poly(caprolactone) (PCL) monofilaments incorporating different amounts of the antiseptic chlorhexidine diacetate (CHX) and evaluated the effect of "online" drawing during the melt spinning or of an "offline" cold drawing on the antimicrobial and physical properties of PCL/CHX monofilaments. The results showed that the drawing conditions strongly affected the properties of the threads. In particular, the filaments exhibited antimicrobial activity for all the draw ratios (DR) adopted, but on increasing DR the antibacterial efficiency reduced. These results were correlated with the CHX surface concentration and with the release kinetics.

Scaffaro, R., Botta, L., Gallo, G., Puglia, A. (2015). Influence of Drawing on the Antimicrobial and Physical Properties of Chlorhexidine-Compounded Poly(caprolactone) Monofilaments. MACROMOLECULAR MATERIALS AND ENGINEERING, 300(12), 1268-1277 [10.1002/mame.201500121].

Influence of Drawing on the Antimicrobial and Physical Properties of Chlorhexidine-Compounded Poly(caprolactone) Monofilaments

SCAFFARO, Roberto;BOTTA, Luigi;GALLO, Giuseppe;PUGLIA, Anna Maria
2015-01-01

Abstract

In this work, we prepared poly(caprolactone) (PCL) monofilaments incorporating different amounts of the antiseptic chlorhexidine diacetate (CHX) and evaluated the effect of "online" drawing during the melt spinning or of an "offline" cold drawing on the antimicrobial and physical properties of PCL/CHX monofilaments. The results showed that the drawing conditions strongly affected the properties of the threads. In particular, the filaments exhibited antimicrobial activity for all the draw ratios (DR) adopted, but on increasing DR the antibacterial efficiency reduced. These results were correlated with the CHX surface concentration and with the release kinetics.
2015
http://www3.interscience.wiley.com/journal/117930403/grouphome/home.html
Scaffaro, R., Botta, L., Gallo, G., Puglia, A. (2015). Influence of Drawing on the Antimicrobial and Physical Properties of Chlorhexidine-Compounded Poly(caprolactone) Monofilaments. MACROMOLECULAR MATERIALS AND ENGINEERING, 300(12), 1268-1277 [10.1002/mame.201500121].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/202026
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