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EnglishPurpose. To study GP-170 in superficial bladder cancer at initial diagnosis and at recurrence and to evaluate if intravesical chemoprophylaxis modifies the expression of GP-170 in tumor recurrence. Materials and Methods. GP-170 was retrospectively assessed in 160 patients affected by primary superficial transitional cell carcinoma of the bladder and followed for up to 10 years. Eighty-four patients (52.5%) recurred after transurethral resection (TUR). Adjuvant intravesical chemotherapy after TUR was adopted in 52 patients. The correlations between GP-170 expression and G-grade and T-category was found. A significant correlation was detected between GP-170 levels were also associated with an increasing risk of recurrence. Intravesical chemotherapy did not induce significative variations in GP-170 expression. No correlation was found between progression and GP-170. Conclusion. GP-170 seems to be an independent prognostic factor for recurrence in superficial bladder tumors. A negative GP-10 pattern and high levels of GP-170 are associated with an increasing risk of recurrence but have no impact upon progression. In our experience, GP-170 is neither induced nor modified by intravesical chemotherapy, although it might represent a factor of chemoresistance when strongly expressed.
Serretta, V., Pavone, C., Allegro, R., Vella, M., Sanguedolce, R., Porcasi, R., et al. (2003). Correlation between GP-170 expression, prognosis, and chemoresistance of superficial bladder carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 129 (8)(129 (8)), 472-476 [DOI: 10.1007/s00432-003-0455-5].
| Data di pubblicazione: | 2003 | |
| Titolo: | Correlation between GP-170 expression, prognosis, and chemoresistance of superficial bladder carcinoma | |
| Autori: | ||
| Citazione: | Serretta, V., Pavone, C., Allegro, R., Vella, M., Sanguedolce, R., Porcasi, R., et al. (2003). Correlation between GP-170 expression, prognosis, and chemoresistance of superficial bladder carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 129 (8)(129 (8)), 472-476 [DOI: 10.1007/s00432-003-0455-5]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/DOI: 10.1007/s00432-003-0455-5 | |
| Abstract: | Purpose. To study GP-170 in superficial bladder cancer at initial diagnosis and at recurrence and to evaluate if intravesical chemoprophylaxis modifies the expression of GP-170 in tumor recurrence. Materials and Methods. GP-170 was retrospectively assessed in 160 patients affected by primary superficial transitional cell carcinoma of the bladder and followed for up to 10 years. Eighty-four patients (52.5%) recurred after transurethral resection (TUR). Adjuvant intravesical chemotherapy after TUR was adopted in 52 patients. The correlations between GP-170 expression and G-grade and T-category was found. A significant correlation was detected between GP-170 levels were also associated with an increasing risk of recurrence. Intravesical chemotherapy did not induce significative variations in GP-170 expression. No correlation was found between progression and GP-170. Conclusion. GP-170 seems to be an independent prognostic factor for recurrence in superficial bladder tumors. A negative GP-10 pattern and high levels of GP-170 are associated with an increasing risk of recurrence but have no impact upon progression. In our experience, GP-170 is neither induced nor modified by intravesical chemotherapy, although it might represent a factor of chemoresistance when strongly expressed. | |
| Settore Scientifico Disciplinare: | Settore MED/24 - Urologia | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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