Interleukin-6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand-binding protein (IL-6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL-6 and a soluble form of the interleukin-6 receptor (sIL-6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL-6 and sIL-6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.
Giannitrapani, L., Cervello, M., Soresi, M., Notarbartolo, M., La Rosa, M., Virruso, L., et al. (2002). Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 963, 46-52.
Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma
GIANNITRAPANI, Lydia;SORESI, Maurizio;VIRRUSO, Lucrezia;D'ALESSANDRO, Natale;MONTALTO, Giuseppe
2002-01-01
Abstract
Interleukin-6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand-binding protein (IL-6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL-6 and a soluble form of the interleukin-6 receptor (sIL-6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL-6 and sIL-6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.
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