Background: The benefit of external radiotherapy for gastric carcinoma has been extensively studied, but data on survival are still equivocal. Objective: To assess the effectiveness of surgery combined with preoperative radiotherapy or postoperative chemoradiotherapy in the reduction of all-cause mortality in patients with resectable gastric carcinoma. Methods: Computerised bibliographic searches of MEDLINE and CANCERLIT (1970–2006) were supplemented with hand searches of reference lists. Study selection: Studies were included if they were randomised controlled trials (RCTs) comparing mortality of surgery combined with preoperative radiotherapy or postoperative chemoradiotherapy to surgery alone, and if they included patients with histologically-proven gastric adenocarcinoma without metastases. Nine eligible RCTs, 4 of preoperative radiotherapy (832 patients) and 5 of postoperative chemoradiotherapy (869 patients), were identified and included in the meta-analysis
FIORICA F, CARTEI F, ENEA M, LICATA A, CABIBBO G, CARAU B, et al. (2007). The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data. CANCER TREATMENT REVIEWS, 33, 729-740 [10.1016/j.ctrv.2007.08.005].
The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data.
ENEA, Marco;LICATA, Anna;CABIBBO, Giuseppe;CAMMA', Calogero
2007-01-01
Abstract
Background: The benefit of external radiotherapy for gastric carcinoma has been extensively studied, but data on survival are still equivocal. Objective: To assess the effectiveness of surgery combined with preoperative radiotherapy or postoperative chemoradiotherapy in the reduction of all-cause mortality in patients with resectable gastric carcinoma. Methods: Computerised bibliographic searches of MEDLINE and CANCERLIT (1970–2006) were supplemented with hand searches of reference lists. Study selection: Studies were included if they were randomised controlled trials (RCTs) comparing mortality of surgery combined with preoperative radiotherapy or postoperative chemoradiotherapy to surgery alone, and if they included patients with histologically-proven gastric adenocarcinoma without metastases. Nine eligible RCTs, 4 of preoperative radiotherapy (832 patients) and 5 of postoperative chemoradiotherapy (869 patients), were identified and included in the meta-analysis
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