The chemical synthesis of new halogenated pyrroles related to pyrrolomycins F is described and the anti-staphylococcal activity compared. The replacement of 4′-bromo atom of parent compounds with two chloro atoms at 3′ and 5′ position increase the antibacterial activity against a reference strain of S. aureus.
RAIMONDI, M.V., SCHILLACI, D., PETRUSO, S. (2007). Synthesis and Anti-Staphylococcal Activity of New Halogenated Pyrroles Related to Pyrrolomycins F. JOURNAL OF HETEROCYCLIC CHEMISTRY, 44(6), 1407-1411 [10.1002/jhet.5570440626].
Synthesis and Anti-Staphylococcal Activity of New Halogenated Pyrroles Related to Pyrrolomycins F
RAIMONDI, Maria Valeria;SCHILLACI, Domenico;PETRUSO, Salvatore
2007-01-01
Abstract
The chemical synthesis of new halogenated pyrroles related to pyrrolomycins F is described and the anti-staphylococcal activity compared. The replacement of 4′-bromo atom of parent compounds with two chloro atoms at 3′ and 5′ position increase the antibacterial activity against a reference strain of S. aureus.
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