Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a given administration. Models based on body anatomy and physiology can provide an accurate description of drug concentrations reached in specific organs and tissues of mammals. This article proposes a model based on mammalian anatomy and physiology to predict the biodistribution in mice of sorafenib, an anti-cancer drug, with specific attention to the concentration reached in the liver, as that is the action site in case of hepatocellular carcinoma treatment. The model reveals a close correspondence respect to experimental concentration data in the organism and also assesses with good fidelity the enterohepatic circulation, a phenomenon occurring at the liver-intestine level and that strongly characterizes sorafenib distribution.

Abbiati, R.A., Cavallaro, G., Craparo, E.F., Manca, D. (2015). Sorafenib in Mice – A Pharmacokinetic Study. CHEMICAL ENGINEERING TRANSACTIONS, 43, 283-288.

Sorafenib in Mice – A Pharmacokinetic Study.

CAVALLARO, Gennara;CRAPARO, Emanuela Fabiola;
2015-01-01

Abstract

Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a given administration. Models based on body anatomy and physiology can provide an accurate description of drug concentrations reached in specific organs and tissues of mammals. This article proposes a model based on mammalian anatomy and physiology to predict the biodistribution in mice of sorafenib, an anti-cancer drug, with specific attention to the concentration reached in the liver, as that is the action site in case of hepatocellular carcinoma treatment. The model reveals a close correspondence respect to experimental concentration data in the organism and also assesses with good fidelity the enterohepatic circulation, a phenomenon occurring at the liver-intestine level and that strongly characterizes sorafenib distribution.
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Abbiati, R.A., Cavallaro, G., Craparo, E.F., Manca, D. (2015). Sorafenib in Mice – A Pharmacokinetic Study. CHEMICAL ENGINEERING TRANSACTIONS, 43, 283-288.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/183516
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