During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.
|Data di pubblicazione:||2007|
|Titolo:||ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO?|
|Autori:||ZUMMO, G; BUCCHIERI, F; CAPPELLO, F; BELLAFIORE, M; LA ROCCA, G; DAVID, S; DI FELICE, V; ANZALONE, R; PERI, G; PALMA, A; FARINA, F|
|Tipologia:||Articolo su rivista|
|Citazione:||ZUMMO, G., BUCCHIERI, F., CAPPELLO, F., BELLAFIORE, M., LA ROCCA, G., DAVID, S., et al. (2007). ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO?. EUROPEAN JOURNAL OF HISTOCHEMISTRY, 51, 83-85.|
|Tipo:||Articolo in rivista|
|Appare nelle tipologie:||01 - Articolo su rivista|