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EnglishDuring embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.
Zummo, G., Bucchieri, F., Cappello, F., Bellafiore, M., LA ROCCA, G., David, S., et al. (2007). ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO?. EUROPEAN JOURNAL OF HISTOCHEMISTRY, 51, 83-85.
| Data di pubblicazione: | 2007 | |
| Titolo: | ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO? | |
| Autori: | ||
| Citazione: | Zummo, G., Bucchieri, F., Cappello, F., Bellafiore, M., LA ROCCA, G., David, S., et al. (2007). ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO?. EUROPEAN JOURNAL OF HISTOCHEMISTRY, 51, 83-85. | |
| Rivista: | ||
| Abstract: | During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/10447/18187
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