In order to develop scaffold able to mimic the natural gradient properties of tissues, biphasic and triphasic approaches were adopted. In this work, polycaprolactone/polyethylene glycol (PCL/PEG) scaffolds were prepared by using a combination of melt mixing and selective leaching without harmful solvents. The method permitted to develop three-layer scaffolds with high control of porosity and pore size. The mechanical properties were evaluated under physiological condition in order to simulate the real conditions of work. Co-culture of osteoblastic and fibroblastic mice cells were carried out in order to study the differential cellular permeation through the different pore size layers.

Scaffaro, R., Lopresti, F., Botta, L., Rigogliuso, S., Ghersi, G. (2016). Melt Processed PCL/PEG Scaffold with Discrete Pore Size Gradient for Selective Cellular Infiltration. MACROMOLECULAR MATERIALS AND ENGINEERING, 301(2), 182-190 [10.1002/mame.201500289].

Melt Processed PCL/PEG Scaffold with Discrete Pore Size Gradient for Selective Cellular Infiltration

SCAFFARO, Roberto;Lopresti, Francesco;BOTTA, Luigi;RIGOGLIUSO, Salvatrice;GHERSI, Giulio
2016-01-01

Abstract

In order to develop scaffold able to mimic the natural gradient properties of tissues, biphasic and triphasic approaches were adopted. In this work, polycaprolactone/polyethylene glycol (PCL/PEG) scaffolds were prepared by using a combination of melt mixing and selective leaching without harmful solvents. The method permitted to develop three-layer scaffolds with high control of porosity and pore size. The mechanical properties were evaluated under physiological condition in order to simulate the real conditions of work. Co-culture of osteoblastic and fibroblastic mice cells were carried out in order to study the differential cellular permeation through the different pore size layers.
2016
Settore BIO/10 - Biochimica
Settore ING-IND/22 - Scienza E Tecnologia Dei Materiali
Settore ING-IND/34 - Bioingegneria Industriale
Scaffaro, R., Lopresti, F., Botta, L., Rigogliuso, S., Ghersi, G. (2016). Melt Processed PCL/PEG Scaffold with Discrete Pore Size Gradient for Selective Cellular Infiltration. MACROMOLECULAR MATERIALS AND ENGINEERING, 301(2), 182-190 [10.1002/mame.201500289].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/181377
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