In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investigate whether donor age and/or long-term culture have any influence on stem cell marker expression and the profiles in the fibroblast-like stem cell population.
Tomasello, L., Musso, R., Cillino, G., Pitrone, M., Pizzolanti, G., Coppola, A., et al. (2016). Donor age and long-term culture do not negatively influence the stem potential of limbal fibroblast-like stem cells. STEM CELL RESEARCH & THERAPY, 7(83) [10.1186/s13287-016-0342-z].
Donor age and long-term culture do not negatively influence the stem potential of limbal fibroblast-like stem cells
TOMASELLO, Laura;MUSSO, Rosa;CILLINO, Giovanni;PITRONE, Maria;PIZZOLANTI, Giuseppe;COPPOLA, Antonina;ARANCIO, Walter;DI CARA, Gianluca;CILLINO, Salvatore;GIORDANO, Carla
2016-01-01
Abstract
In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investigate whether donor age and/or long-term culture have any influence on stem cell marker expression and the profiles in the fibroblast-like stem cell population.
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