Chronic myeloid leukemia is a myeloproliferative disorder that comes from a hematopoietic stem cell or a multipotent progenitor. Exosomes are biological nanovescicles (40-100 nm) able to modulate intercellular communication and tumour microenvironment; they also contain miRNAs that can influence gene expression in target cells. OncomiRNAs, such as miR-21, are often increased in cancer. Some observation indicate a possible cellular disposal of miRNAs by exosomes. Curcumin affects the expression of microRNAs in CML cells and according to our data may play a role in this process.
Taverna, S., Giallombardo, M., Flugy, A., Rolfo, C., Pucci, M., DE LEO, G., et al. (2015). Curcumin induces selective packaging of miR-21 in exosomes released by Chronic Myelogenous Leukemia cells. In ISEV.
Autori: | Taverna, S.; Giallombardo, M.; Flugy, A.; Rolfo, C.; Pucci, M.; DE LEO, G.; Alessandro, R. | |
Titolo: | Curcumin induces selective packaging of miR-21 in exosomes released by Chronic Myelogenous Leukemia cells | |
Nome del convegno: | ISEV | |
Data di pubblicazione: | 2015 | |
Numero di pagine: | 1 | |
Citazione: | Taverna, S., Giallombardo, M., Flugy, A., Rolfo, C., Pucci, M., DE LEO, G., et al. (2015). Curcumin induces selective packaging of miR-21 in exosomes released by Chronic Myelogenous Leukemia cells. In ISEV. | |
Tipologia: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) | |
Appare nelle tipologie: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) |