The role of vascular renal changes in mediating the association between serum uric acid (SUA) and renal damage is unclear. The purposes of this study were to investigate the relationship between SUA and renal resistive index (RRI), assessed by duplex Doppler ultrasonography, and to assess whether hemodynamic renal changes may explain the association between SUA and renal damage in hypertensive patients. A total of 530 hypertensive patients with and without chronic kidney disease were enrolled and divided into SUA tertiles based on sex-specific cutoff values. RRI and albuminuria were greater and glomerular filtration rate (GFR) was lower in the uppermost SUA tertile patients when compared with those in the lowest tertiles (all P<.001). Moreover, SUA strongly correlated with RRI (P<.001) in all patients. However, RRI did not seem to explain the relationship between SUA and renal damage, and GFR significantly related with SUA in the overall population (P<.001) even after adjustment for RRI.

Geraci, G., Mulè, G., Mogavero, M., Geraci, C., Nardi, E., Cottone, S. (2016). Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients. THE JOURNAL OF CLINICAL HYPERTENSION, 18(10), 1007-1014 [10.1111/jch.12812].

Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients

GERACI, Giulio
;
MULE', Giuseppe;MOGAVERO, Manuela;GERACI, Calogero;NARDI, Emilio;COTTONE, Santina
2016-01-01

Abstract

The role of vascular renal changes in mediating the association between serum uric acid (SUA) and renal damage is unclear. The purposes of this study were to investigate the relationship between SUA and renal resistive index (RRI), assessed by duplex Doppler ultrasonography, and to assess whether hemodynamic renal changes may explain the association between SUA and renal damage in hypertensive patients. A total of 530 hypertensive patients with and without chronic kidney disease were enrolled and divided into SUA tertiles based on sex-specific cutoff values. RRI and albuminuria were greater and glomerular filtration rate (GFR) was lower in the uppermost SUA tertile patients when compared with those in the lowest tertiles (all P<.001). Moreover, SUA strongly correlated with RRI (P<.001) in all patients. However, RRI did not seem to explain the relationship between SUA and renal damage, and GFR significantly related with SUA in the overall population (P<.001) even after adjustment for RRI.
Settore MED/09 - Medicina Interna
Settore MED/14 - Nefrologia
https://onlinelibrary.wiley.com/doi/10.1111/jch.12812
Geraci, G., Mulè, G., Mogavero, M., Geraci, C., Nardi, E., Cottone, S. (2016). Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients. THE JOURNAL OF CLINICAL HYPERTENSION, 18(10), 1007-1014 [10.1111/jch.12812].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/175112
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