Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.

Sinagra, E., Pompei, G., Tomasello, G., Cappello, F., Morreale, G.C., Amvrosiadis, G., et al. (2016). INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?. WORLD JOURNAL OF GASTROENTEROLOGY, 7(7), 2242-2255 [10.3748/wjg.v22.i7.2242].

INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?

SINAGRA, Emanuele
;
TOMASELLO, Giovanni;CAPPELLO, Francesco;LO MONTE, Attilio Ignazio;
2016

Abstract

Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.
Settore MED/18 - Chirurgia Generale
Settore MED/12 - Gastroenterologia
Settore BIO/16 - Anatomia Umana
Sinagra, E., Pompei, G., Tomasello, G., Cappello, F., Morreale, G.C., Amvrosiadis, G., et al. (2016). INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?. WORLD JOURNAL OF GASTROENTEROLOGY, 7(7), 2242-2255 [10.3748/wjg.v22.i7.2242].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/168481
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