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EnglishMyc promoter-binding protein-1 (MBP-1) is a shorter protein variant of the glycolytic enzyme alpha-enolase. Although several lines of evidence indicate that MBP-1 acts as a tumor suppressor, the cellular mechanisms and signaling pathways underlying MBP-1 expression still remain largely elusive. To dissect these pathways, we used the SkBr3 breast cancer cell line and non-tumorigenic HEK293T cells ectopically overexpressing alpha-enolase/MBP-1. Here, we demonstrate that induced cell stresses promote MBP-1 expression through the AKT/PERK/eIF2α signaling axis. Our results contribute to shedding light on the molecular mechanisms underlying MBP-1 expression in non-tumorigenic and cancer cells
Maranto, C., Perconti, G., Contino, F., Rubino, P., Feo, S., & Giallongo, A. (2015). Cellular stress induces cap-independent alpha-enolase/MBP-1 translation. FEBS LETTERS, 589(16), 2110-2116 [10.1016/j.febslet.2015.06.030].
| Data di pubblicazione: | 2015 | |
| Titolo: | Cellular stress induces cap-independent alpha-enolase/MBP-1 translation | |
| Autori: | ||
| Citazione: | Maranto, C., Perconti, G., Contino, F., Rubino, P., Feo, S., & Giallongo, A. (2015). Cellular stress induces cap-independent alpha-enolase/MBP-1 translation. FEBS LETTERS, 589(16), 2110-2116 [10.1016/j.febslet.2015.06.030]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.febslet.2015.06.030 | |
| Abstract: | Myc promoter-binding protein-1 (MBP-1) is a shorter protein variant of the glycolytic enzyme alpha-enolase. Although several lines of evidence indicate that MBP-1 acts as a tumor suppressor, the cellular mechanisms and signaling pathways underlying MBP-1 expression still remain largely elusive. To dissect these pathways, we used the SkBr3 breast cancer cell line and non-tumorigenic HEK293T cells ectopically overexpressing alpha-enolase/MBP-1. Here, we demonstrate that induced cell stresses promote MBP-1 expression through the AKT/PERK/eIF2α signaling axis. Our results contribute to shedding light on the molecular mechanisms underlying MBP-1 expression in non-tumorigenic and cancer cells | |
| URL: | http://www.sciencedirect.com/science/article/pii/S0014579315005645 | |
| Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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