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EnglishSubnanometric samples, containing exclusively Ag<inf>2</inf> and Ag<inf>3</inf> clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we show herein that Ag<inf>3</inf> clusters interact with DNA through intercalation, inducing significant structural distortion to the DNA. The lifetime of Ag<inf>3</inf> clusters in the intercalated position is two to three orders of magnitude longer than for classical organic intercalators, such as ethidium bromide or proflavine.
| Data di pubblicazione: | 2015 |
| Titolo: | Ag<inf>2</inf> and Ag<inf>3</inf> Clusters: Synthesis, Characterization, and Interaction with DNA |
| Autori: | |
| Citazione: | Buceta, D., Busto, N., Barone, G., Leal, J., Domínguez, F., Giovanetti, L., et al. (2015). Ag<inf>2</inf> and Ag<inf>3</inf> Clusters: Synthesis, Characterization, and Interaction with DNA. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 54(26), 7612-7616. |
| Rivista: | |
| Digital Object Identifier (DOI): | 10.1002/anie.201502917 |
| Abstract: | Subnanometric samples, containing exclusively Ag<inf>2</inf> and Ag<inf>3</inf> clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we show herein that Ag<inf>3</inf> clusters interact with DNA through intercalation, inducing significant structural distortion to the DNA. The lifetime of Ag<inf>3</inf> clusters in the intercalated position is two to three orders of magnitude longer than for classical organic intercalators, such as ethidium bromide or proflavine. |
| URL: | http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3773 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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