Ag2 and Ag3 Clusters: Synthesis, Characterization, and Interaction with DNA

Buceta, D; Busto, N; Barone, G; Leal, J; Domínguez, F; Giovanetti, L; Requejo, F; García, B; Lõpez Quintela, M

doi:10.1002/anie.201502917

Subnanometric samples, containing exclusively Ag2 and Ag3 clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we show herein that Ag3 clusters interact with DNA through intercalation, inducing significant structural distortion to the DNA. The lifetime of Ag3 clusters in the intercalated position is two to three orders of magnitude longer than for classical organic intercalators, such as ethidium bromide or proflavine.

Buceta, D., Busto, N., Barone, G., Leal, J., Domínguez, F., Giovanetti, L., et al. (2015). Ag2 and Ag3 Clusters: Synthesis, Characterization, and Interaction with DNA. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 54(26), 7612-7616 [10.1002/anie.201502917].

Data di pubblicazione:	2015-06-22
Titolo:	Ag2 and Ag3 Clusters: Synthesis, Characterization, and Interaction with DNA
Autori:	Buceta, D. [Membro del Collaboration Group] Busto, N. [Membro del Collaboration Group] BARONE, Giampaolo [Membro del Collaboration Group] Leal, J. [Membro del Collaboration Group] Domínguez, F. [Membro del Collaboration Group] Giovanetti, L. [Membro del Collaboration Group] Requejo, F. [Membro del Collaboration Group] García, B. [Membro del Collaboration Group] (Corresponding) Lõpez Quintela, M. [Membro del Collaboration Group] (Corresponding) mostra contributor esterni nascondi contributor esterni
Citazione:	Buceta, D., Busto, N., Barone, G., Leal, J., Domínguez, F., Giovanetti, L., et al. (2015). Ag2 and Ag3 Clusters: Synthesis, Characterization, and Interaction with DNA. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 54(26), 7612-7616 [10.1002/anie.201502917].
Rivista:	ANGEWANDTE CHEMIE. INTERNATIONAL EDITION
Digital Object Identifier (DOI):	http://dx.doi.org/10.1002/anie.201502917
Abstract:	Subnanometric samples, containing exclusively Ag2 and Ag3 clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we show herein that Ag3 clusters interact with DNA through intercalation, inducing significant structural distortion to the DNA. The lifetime of Ag3 clusters in the intercalated position is two to three orders of magnitude longer than for classical organic intercalators, such as ethidium bromide or proflavine.
URL dell'editore:	https://onlinelibrary.wiley.com/doi/10.1002/anie.201502917
Settore Scientifico Disciplinare:	Settore CHIM/03 - Chimica Generale E Inorganica
Appare nelle tipologie:	1.01 Articolo in rivista

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http://hdl.handle.net/10447/167727

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