3-(1-Phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones 14a–q and 15a–q were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 12 and 13 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 14a–q and 15a–q were tested in vitro for their antileukemic activity against L1210 (murine leukemia), K562 (human chronic myelogenous leukemia) and HL60 (human leukemia) cell lines showing in some cases good activity.
RAFFA D, DAIDONE G, MAGGIO B, CASCIOFERRO S, PLESCIA F, SCHILLACI D (2004). SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF NEW 3-(1-PHENYL-3-METHYLPYRAZOL-5-YL)-2-STYRYLQUINAZOLIN-4(3H)-ONES. IL FARMACO, 59(3), 215-221 [10.1016/j.farmac.2003.10.004].
SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF NEW 3-(1-PHENYL-3-METHYLPYRAZOL-5-YL)-2-STYRYLQUINAZOLIN-4(3H)-ONES
RAFFA, Demetrio;DAIDONE, Giuseppe;MAGGIO, Benedetta;CASCIOFERRO, Stella Maria;PLESCIA, Fabiana;SCHILLACI, Domenico
2004-01-01
Abstract
3-(1-Phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones 14a–q and 15a–q were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 12 and 13 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 14a–q and 15a–q were tested in vitro for their antileukemic activity against L1210 (murine leukemia), K562 (human chronic myelogenous leukemia) and HL60 (human leukemia) cell lines showing in some cases good activity.
| File | Dimensione | Formato | |
|---|---|---|---|
|
1-s2.0-S0014827X03002842-main.pdf
Solo gestori archvio
Descrizione: Articolo
Dimensione
198.32 kB
Formato
Adobe PDF
|
198.32 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
