Objective: In order to evaluate radicality in fertility preserving surgery in women with early invasive cervical cancer we analyzed the parametrium of specimens of patients treated by radical vaginal trachelectomy for the presence of lymph nodes. We tried to identify morphologic factors associated with the presence of parametrial lymph nodes. Methods: We analyzed surgical specimens of 112 patients who underwent radical trachelectomy between June 2004 and April 2009 at the Department of Gynecologic Oncology at Charité Campus Benjamin Franklin and Campus Mitte. All parametrial tissue was step sectioned and a total of 1878H&E stained histological sections were analyzed. Results: In 8 patients (7.1%) a total of 13 lymph nodes were detected. Five lymph nodes in four patients had been primarily detected by routine histological examination. In one of these patients (0.9%) a 2 mm lymph node metastasis was found. Serial sectioning revealed additional seven lymph nodes in four patients. The thickness of parametrium correlated significantly with the presence of lymph nodes in the parametrium. Conclusion: The presence of small lymph nodes in the parametrium of specimens of radical trachelectomy is low. In patients with early-stage cervical cancer, the incidence of metastasis is less than 1%. Preoperative assessment of the volume of the parametrium may indicate which patients need parametrial resection. © 2011 Elsevier Inc. All rights reserved.

Lanowska, M., Morawietz, L., Sikora, A., Räber, G., Mangler, M., Speiser, D., et al. (2011). Prevalence of lymph nodes in the parametrium of radical vaginal trachelectomy (RVT) specimen. GYNECOLOGIC ONCOLOGY, 121(2), 298-302 [10.1016/j.ygyno.2011.01.011].

Prevalence of lymph nodes in the parametrium of radical vaginal trachelectomy (RVT) specimen

Chiantera, Vito;
2011-01-01

Abstract

Objective: In order to evaluate radicality in fertility preserving surgery in women with early invasive cervical cancer we analyzed the parametrium of specimens of patients treated by radical vaginal trachelectomy for the presence of lymph nodes. We tried to identify morphologic factors associated with the presence of parametrial lymph nodes. Methods: We analyzed surgical specimens of 112 patients who underwent radical trachelectomy between June 2004 and April 2009 at the Department of Gynecologic Oncology at Charité Campus Benjamin Franklin and Campus Mitte. All parametrial tissue was step sectioned and a total of 1878H&E stained histological sections were analyzed. Results: In 8 patients (7.1%) a total of 13 lymph nodes were detected. Five lymph nodes in four patients had been primarily detected by routine histological examination. In one of these patients (0.9%) a 2 mm lymph node metastasis was found. Serial sectioning revealed additional seven lymph nodes in four patients. The thickness of parametrium correlated significantly with the presence of lymph nodes in the parametrium. Conclusion: The presence of small lymph nodes in the parametrium of specimens of radical trachelectomy is low. In patients with early-stage cervical cancer, the incidence of metastasis is less than 1%. Preoperative assessment of the volume of the parametrium may indicate which patients need parametrial resection. © 2011 Elsevier Inc. All rights reserved.
2011
Lanowska, M., Morawietz, L., Sikora, A., Räber, G., Mangler, M., Speiser, D., et al. (2011). Prevalence of lymph nodes in the parametrium of radical vaginal trachelectomy (RVT) specimen. GYNECOLOGIC ONCOLOGY, 121(2), 298-302 [10.1016/j.ygyno.2011.01.011].
File in questo prodotto:
File Dimensione Formato  
Articolo Chiantera1.pdf

Solo gestori archvio

Descrizione: pdf articolo
Dimensione 314.73 kB
Formato Adobe PDF
314.73 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/165592
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 19
social impact