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EnglishRadiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio)conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.
| Data di pubblicazione: | 2016 |
| Titolo: | On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions |
| Autori: | |
| Citazione: | Dispenza, C., Sabatino, M., Grimaldi, N., Mangione, M., Walo, M., Murugan, E., et al. (2016). On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions. RSC ADVANCES, 6(4), 2582-2591. |
| Rivista: | |
| Digital Object Identifier (DOI): | 10.1039/c5ra23926e |
| Abstract: | Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio)conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers. |
| URL: | http://pubs.rsc.org/en/journals/journalissues |
| Settore Scientifico Disciplinare: | Settore CHIM/07 - Fondamenti Chimici Delle Tecnologie |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 2016 Dispenza-et al RSC_Advances.pdf | N/A | Administrator Richiedi una copia |
http://hdl.handle.net/10447/165274
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