The present study investigated primary human hepatocyte cultures obtained from liver specimens of patients affected by cirrhosis and HCC, their proliferation and transformation. The degree of invasiveness of cells acquiring neoplastic characteristics was studied with a transwell migration assay. With the present study, we are the first to have identified and describe the existence of human hepatocytes near the cancerous lesion that can transform in HCC in vitro.
Montalbano, M., Rastellini, C., Wang, X., Corsello, T., Eltorky, M., Vento, R., et al. (2015). Transformation of primary human hepatocytes in hepatocellular carcinoma. INTERNATIONAL JOURNAL OF ONCOLOGY, 48(3), 1205-1217 [10.3892/ijo.2015.3312].
Transformation of primary human hepatocytes in hepatocellular carcinoma.
MONTALBANO, Mauro;CORSELLO, Tiziana;VENTO, Renza;
2015-01-01
Abstract
The present study investigated primary human hepatocyte cultures obtained from liver specimens of patients affected by cirrhosis and HCC, their proliferation and transformation. The degree of invasiveness of cells acquiring neoplastic characteristics was studied with a transwell migration assay. With the present study, we are the first to have identified and describe the existence of human hepatocytes near the cancerous lesion that can transform in HCC in vitro.
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