MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease

Petta, S; Valenti, L; Marra, F; Grimaudo, S; Tripodo, C; Bugianesi, E; Camma', C; Cappon, A; Marco, V; Maira, G; Dongiovanni, P; Rametta, R; Gulino, A; Mozzi, E; Orlando, E; Maggioni, M; Pipitone, RM; Fargion, S; Craxi, A

doi:10.1016/j.jhep.2015.10.016

Homozygosity for a common non-coding rs4374383 G>A polymorphism in MERTK has been associated with protection against fibrosis progression in chronic hepatitis C. The main study objective was to assess whether MERTK AA genotype influences liver fibrosis, and secondarily MERTK expression in patients with NAFLD. We also investigated whether MERTK is expressed in human hepatic stellate cells (HSC) and in murine models of fibrogenesis.

Petta, S., Valenti, L., Marra, F., Grimaudo, S., Tripodo, C., Bugianesi, E., et al. (2015). MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease. JOURNAL OF HEPATOLOGY [10.1016/j.jhep.2015.10.016].

Data di pubblicazione:	2015
Titolo:	MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease
Autori:	PETTA, Salvatore Valenti, L. Marra, F. GRIMAUDO, Stefania TRIPODO, Claudio Bugianesi, E. CAMMA', Calogero Cappon, A. Marco, V. Maira, G. Dongiovanni, P. Rametta, R. GULINO, Alessandro Mozzi, E. ORLANDO, Emanuele Maggioni, M. PIPITONE, Rosaria Maria Fargion, S. CRAXI, Antonio mostra contributor esterni nascondi contributor esterni
Citazione:	Petta, S., Valenti, L., Marra, F., Grimaudo, S., Tripodo, C., Bugianesi, E., et al. (2015). MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease. JOURNAL OF HEPATOLOGY [10.1016/j.jhep.2015.10.016].
Rivista:	JOURNAL OF HEPATOLOGY
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.jhep.2015.10.016
Abstract:	Homozygosity for a common non-coding rs4374383 G>A polymorphism in MERTK has been associated with protection against fibrosis progression in chronic hepatitis C. The main study objective was to assess whether MERTK AA genotype influences liver fibrosis, and secondarily MERTK expression in patients with NAFLD. We also investigated whether MERTK is expressed in human hepatic stellate cells (HSC) and in murine models of fibrogenesis.
Appare nelle tipologie:	1.01 Articolo in rivista

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http://hdl.handle.net/10447/159327

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