1,2,4-Oxadiazoles experienced an almost 80-year long period of scientific lethargy before they tickled the curiosity of chemists. The study of chemical and photochemical reactivity of 1,2,4-oxadiazoles opened the way to a series of applications in heterocyclic synthesis. Today, 1,2,4-oxadiazoles are known in medicinal chemistry for their use as bioisosters of esters and amides. Furthermore, fluorinated 1,2,4-oxadiazoles have been applied in materials science either by themselves or for the targeted modification of polymers and macromolecules. Overall, the synthesis of 1,2,4-oxadiazoles can be planned to fine-tune their properties for featured applications. Their versatility, either as starting synthons or as target compounds, has boosted the number of studies involving 1,2,4-oxadiazoles in the last decade. This review presents a selection of 1,2,4-oxadiazoles applications in materials science and medicinal chemistry.

Pace, A., Buscemi, S., Palumbo Piccionello, A., Pibiri, I. (2015). Recent Advances in the Chemistry of 1,2,4-Oxadiazoles. In Advances in Heterocyclic Chemistry [10.1016/bs.aihch.2015.05.001].

Recent Advances in the Chemistry of 1,2,4-Oxadiazoles

PACE, Andrea;BUSCEMI, Silvestre;PALUMBO PICCIONELLO, Antonio;PIBIRI, Ivana
2015-01-01

Abstract

1,2,4-Oxadiazoles experienced an almost 80-year long period of scientific lethargy before they tickled the curiosity of chemists. The study of chemical and photochemical reactivity of 1,2,4-oxadiazoles opened the way to a series of applications in heterocyclic synthesis. Today, 1,2,4-oxadiazoles are known in medicinal chemistry for their use as bioisosters of esters and amides. Furthermore, fluorinated 1,2,4-oxadiazoles have been applied in materials science either by themselves or for the targeted modification of polymers and macromolecules. Overall, the synthesis of 1,2,4-oxadiazoles can be planned to fine-tune their properties for featured applications. Their versatility, either as starting synthons or as target compounds, has boosted the number of studies involving 1,2,4-oxadiazoles in the last decade. This review presents a selection of 1,2,4-oxadiazoles applications in materials science and medicinal chemistry.
2015
Settore CHIM/06 - Chimica Organica
Pace, A., Buscemi, S., Palumbo Piccionello, A., Pibiri, I. (2015). Recent Advances in the Chemistry of 1,2,4-Oxadiazoles. In Advances in Heterocyclic Chemistry [10.1016/bs.aihch.2015.05.001].
File in questo prodotto:
File Dimensione Formato  
2015AdvHetChem.pdf

Solo gestori archvio

Dimensione 6.04 MB
Formato Adobe PDF
6.04 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/152091
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 63
  • ???jsp.display-item.citation.isi??? 60
social impact