Multiple sclerosis (MS) is a cell-mediated autoimmune disease characterized by type-1 cytokine production. Environmental and individual genetic background might influence this response particularly in cytokine gene polymorphisms. We evaluated whether polymorphisms of interleukin (IL)-10, IL-12, and tumor necrosis factor (TNF)-α genes, which might play a role in MS pathogenesis, are associated with MS susceptibility. Genotype frequencies for all the analyzed polymorphisms were not differently distributed between cases and controls. It is reasonable to suppose that the cytokine single-nucleotide polymorphisms (SNPs) studied must be considered against a larger genetic background involving other functional SNPs of Th1 regulator elements such as IL-21 and IL-23.

FORTE GI, RAGONESE P, SALEMI G, SCOLA L, CANDORE G, D'AMELIO M, et al. (2006). Search for genetic factors associated with susceptibility to multiple sclerosis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1067, 264-269 [10.1196/annals.1354.034].

Search for genetic factors associated with susceptibility to multiple sclerosis.

FORTE, Giusi Irma;RAGONESE, Paolo;SALEMI, Giuseppe;SCOLA, Letizia;CANDORE, Giuseppina;D'AMELIO, Marco;CRIVELLO, Antonino;DI BENEDETTO, Norma;NUZZO, Domenico;LIO, Domenico;CARUSO, Calogero
2006-01-01

Abstract

Multiple sclerosis (MS) is a cell-mediated autoimmune disease characterized by type-1 cytokine production. Environmental and individual genetic background might influence this response particularly in cytokine gene polymorphisms. We evaluated whether polymorphisms of interleukin (IL)-10, IL-12, and tumor necrosis factor (TNF)-α genes, which might play a role in MS pathogenesis, are associated with MS susceptibility. Genotype frequencies for all the analyzed polymorphisms were not differently distributed between cases and controls. It is reasonable to suppose that the cytokine single-nucleotide polymorphisms (SNPs) studied must be considered against a larger genetic background involving other functional SNPs of Th1 regulator elements such as IL-21 and IL-23.
2006
FORTE GI, RAGONESE P, SALEMI G, SCOLA L, CANDORE G, D'AMELIO M, et al. (2006). Search for genetic factors associated with susceptibility to multiple sclerosis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1067, 264-269 [10.1196/annals.1354.034].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/15086
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