Multiple sclerosis (MS) is a cell-mediated autoimmune disease characterized by type-1 cytokine production. Environmental and individual genetic background might influence this response particularly in cytokine gene polymorphisms. We evaluated whether polymorphisms of interleukin (IL)-10, IL-12, and tumor necrosis factor (TNF)-α genes, which might play a role in MS pathogenesis, are associated with MS susceptibility. Genotype frequencies for all the analyzed polymorphisms were not differently distributed between cases and controls. It is reasonable to suppose that the cytokine single-nucleotide polymorphisms (SNPs) studied must be considered against a larger genetic background involving other functional SNPs of Th1 regulator elements such as IL-21 and IL-23.
|Data di pubblicazione:||2006|
|Titolo:||Search for genetic factors associated with susceptibility to multiple sclerosis.|
|Autori:||FORTE GI; RAGONESE P; SALEMI G; SCOLA L; CANDORE G; D'AMELIO M; CRIVELLO A; DI BENEDETTO N; NUZZO D; GIACALONE A; LIO D; CARUSO C|
|Tipologia:||Articolo su rivista|
|Citazione:||FORTE GI, RAGONESE P, SALEMI G, SCOLA L, CANDORE G, D'AMELIO M, et al. (2006). Search for genetic factors associated with susceptibility to multiple sclerosis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1067, 264-269.|
|Digital Object Identifier (DOI):||10.1196/annals.1354.034|
|Appare nelle tipologie:||01 - Articolo su rivista|