Abstract Foams with a pore size gradient are promising materials for tissue engineering applications where a complex architecture involving morphological variations in space must be mimicked, e.g. in bone tissue repair. In this paper, a technique to obtain a porous scaffold with a pore size gradient is presented. The preparation procedure is based on Thermally Induced Phase Separation (TIPS), by imposing a different thermal history on the two sides of a polymeric solution. In this way, a gradient in thermal history is produced, which will generate a pore size monotonously varying along scaffold thickness. By controlling some parameters easy to manipulate, such as demixing temperature and/or residence time in the miscibility gap region, the pore size range can be easily tuned.

Mannella, G., Conoscenti, G., CARFI' PAVIA, F., LA CARRUBBA, V., Brucato, V. (2015). Preparation of polymeric foams with a pore size gradient via Thermally Induced Phase Separation (TIPS). MATERIALS LETTERS, 160, 31-33 [10.1016/j.matlet.2015.07.055].

Preparation of polymeric foams with a pore size gradient via Thermally Induced Phase Separation (TIPS)

MANNELLA, Gianluca Antonio
;
Conoscenti, Gioacchino;CARFI' PAVIA, Francesco;LA CARRUBBA, Vincenzo;BRUCATO, Valerio Maria Bartolo
2015-01-01

Abstract

Abstract Foams with a pore size gradient are promising materials for tissue engineering applications where a complex architecture involving morphological variations in space must be mimicked, e.g. in bone tissue repair. In this paper, a technique to obtain a porous scaffold with a pore size gradient is presented. The preparation procedure is based on Thermally Induced Phase Separation (TIPS), by imposing a different thermal history on the two sides of a polymeric solution. In this way, a gradient in thermal history is produced, which will generate a pore size monotonously varying along scaffold thickness. By controlling some parameters easy to manipulate, such as demixing temperature and/or residence time in the miscibility gap region, the pore size range can be easily tuned.
2015
Settore ING-IND/34 - Bioingegneria Industriale
Mannella, G., Conoscenti, G., CARFI' PAVIA, F., LA CARRUBBA, V., Brucato, V. (2015). Preparation of polymeric foams with a pore size gradient via Thermally Induced Phase Separation (TIPS). MATERIALS LETTERS, 160, 31-33 [10.1016/j.matlet.2015.07.055].
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0167577X15302470-main.pdf

Solo gestori archvio

Dimensione 1.61 MB
Formato Adobe PDF
1.61 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/149140
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 49
  • ???jsp.display-item.citation.isi??? 42
social impact