Time-resolved structural information is key to understand the mechanism of biological processes, such as catalysis and signalling. Recent developments in X-ray sources as well as data collection and analysis methods are making routine time-resolved X-ray crystallography and solution scattering experiments a real possibility for structural biologists. Here we review the information that can be obtained from these techniques and discuss the considerations that must be taken into account when designing a time-resolved experiment.

Levantino, M., Yorke, B.A., Monteiro, D., Cammarata, M., Pearson, A.R. (2015). Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules. CURRENT OPINION IN STRUCTURAL BIOLOGY, 35, 41-48 [10.1016/j.sbi.2015.07.017].

Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules

LEVANTINO, Matteo;
2015-01-01

Abstract

Time-resolved structural information is key to understand the mechanism of biological processes, such as catalysis and signalling. Recent developments in X-ray sources as well as data collection and analysis methods are making routine time-resolved X-ray crystallography and solution scattering experiments a real possibility for structural biologists. Here we review the information that can be obtained from these techniques and discuss the considerations that must be taken into account when designing a time-resolved experiment.
2015
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Levantino, M., Yorke, B.A., Monteiro, D., Cammarata, M., Pearson, A.R. (2015). Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules. CURRENT OPINION IN STRUCTURAL BIOLOGY, 35, 41-48 [10.1016/j.sbi.2015.07.017].
File in questo prodotto:
File Dimensione Formato  
2015_CurrOpinStructBiol_35_41_Levantino_et_al.pdf

accesso aperto

Dimensione 926.53 kB
Formato Adobe PDF
926.53 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/148117
Citazioni
  • ???jsp.display-item.citation.pmc??? 32
  • Scopus 87
  • ???jsp.display-item.citation.isi??? 85
social impact