Angiogenesis is strongly influenced by vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF), whose production is also regulated by interferon (IFN)-gamma and interleukin (IL)-10. The aim of this study was to evaluate the modifications of serum VEGF, b-FGF, IFN-gamma and IL-10 levels in patients with inguinal hernia undergoing hernioplasty with the Lichtenstein technique (LH) using polypropylene mesh or with Bassini open conventional inguinal hernia repair (BH). MATERIALS AND METHODS: Randomly, 16 patients underwent BH, and 16 were treated with the LH technique using polypropylene mesh. Blood samples were collected 24 h prior to surgery and then 6, 24, 48 and 168 h postoperatively. The serum concentrations of VEGF, b-FGF, IFN-gamma and IL-10 were evaluated. RESULTS: In BH patients, a peak of VEGF synthesis at 6 h with a normalization of this parameter 24 h after surgery has been observed. In the same subjects, b-FGF synthesis increased after surgery reaching significant levels 48 h later. On the contrary, in LH patients, a decrease in the serum VEGF and b-FGF concentrations was detected after surgery and their increase afterwards. IL-10 was increased in both groups 6 h after operation and declined to preoperative levels 24 h afterwards. IFN-gamma enhanced in LH patients 6 h after surgery, whereas no modifications were detected in BH subjects. CONCLUSIONS: This preliminary study shows that VEGF and b-FGF modifications, associated with alterations of cytokine secretion, are detectable in human undergoing hernioplasty, and suggests that they could somehow influence in the wound-healing process.
DI VITA, G., Patti, R., D'Agostino, P., Arcoleo, F., Arcara, M., Davi', V., et al. (2005). Serum VEGF and b-FGF profiles after tension-free or conventional hernioplasty. LANGENBECK'S ARCHIVES OF SURGERY, 390(6), 528-533 [10.1007/s00423-005-0578-z].
|Data di pubblicazione:||2005|
|Titolo:||Serum VEGF and b-FGF profiles after tension-free or conventional hernioplasty.|
|Citazione:||DI VITA, G., Patti, R., D'Agostino, P., Arcoleo, F., Arcara, M., Davi', V., et al. (2005). Serum VEGF and b-FGF profiles after tension-free or conventional hernioplasty. LANGENBECK'S ARCHIVES OF SURGERY, 390(6), 528-533 [10.1007/s00423-005-0578-z].|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00423-005-0578-z|
|Appare nelle tipologie:||1.01 Articolo in rivista|
File in questo prodotto:
|Vita2005_Article_SerumVEGFAndB-FGFProfilesAfter.pdf||N/A||Administrator Richiedi una copia|