We report the case of a 38-year-old woman treated with lamotrigine who experienced multi-organ dysfunction. The patient received the drug at the dose of 100 mg per day. One week later, the treatment was suspended because of an extensive body rash. Twenty-four hours later, the patient appeared drowsy and stuporous and was hospitalized. On the fifth day, the patient was admitted with a clinical picture of acute multi-organ failure in our Institute, where, she, despite the support of vital functions with vasoactive drugs, continuous hemofiltration and ventilation with oxygen, died. Serum lamotrigine concentration was measured 110 h after its last dose and the drug resulted to be still present at 1 mg/L. The patient was homozygous for the UGT1A4-70C and UGT2B7-161C alleles and heterozygous for the UGT2B7-372A>G polymorphism. Regarding ABCB1 the patient showed the 3435CC, 2677GT and 1236CT genotypes.

Provenzani, A., Labbozzetta, M., NOTARBARTOLO DI VILLAROSA, M., Poma, P., Polidori, P., Vizzini, G., et al. (2015). Rash and multiorgan dysfunction following lamotrigine: could genetic be involved?. INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, 37(5), 682-686 [10.1007/s11096-015-0158-4].

Rash and multiorgan dysfunction following lamotrigine: could genetic be involved?

LABBOZZETTA, Manuela;NOTARBARTOLO DI VILLAROSA, Monica;POMA, Paola;D'ALESSANDRO, Natale
2015-01-01

Abstract

We report the case of a 38-year-old woman treated with lamotrigine who experienced multi-organ dysfunction. The patient received the drug at the dose of 100 mg per day. One week later, the treatment was suspended because of an extensive body rash. Twenty-four hours later, the patient appeared drowsy and stuporous and was hospitalized. On the fifth day, the patient was admitted with a clinical picture of acute multi-organ failure in our Institute, where, she, despite the support of vital functions with vasoactive drugs, continuous hemofiltration and ventilation with oxygen, died. Serum lamotrigine concentration was measured 110 h after its last dose and the drug resulted to be still present at 1 mg/L. The patient was homozygous for the UGT1A4-70C and UGT2B7-161C alleles and heterozygous for the UGT2B7-372A>G polymorphism. Regarding ABCB1 the patient showed the 3435CC, 2677GT and 1236CT genotypes.
Settore BIO/14 - Farmacologia
Provenzani, A., Labbozzetta, M., NOTARBARTOLO DI VILLAROSA, M., Poma, P., Polidori, P., Vizzini, G., et al. (2015). Rash and multiorgan dysfunction following lamotrigine: could genetic be involved?. INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, 37(5), 682-686 [10.1007/s11096-015-0158-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/147599
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