A new, simple, one-step synthetic route to carbamo(dithioperoxo)thioates from commercially available starting materials is described. The key step of this new synthetic approach involves the tetrabromomethane-promoted reaction between secondary amines, carbon disulfide and alkyl thiols under basic conditions at room temperature. New compounds from this series selected for anticancer screening showed selective sub-micromolar activity within BCA2-expressing human breast cancer cell lines.
Cilibrasi, V., Tsang, K., Morelli, M., Solfa, F., Wiggins, H., Jones, A., et al. (2015). Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. TETRAHEDRON LETTERS, 56(20), 2583-2585 [10.1016/j.tetlet.2015.03.132].
Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents
CILIBRASI, Vincenzo;
2015-01-01
Abstract
A new, simple, one-step synthetic route to carbamo(dithioperoxo)thioates from commercially available starting materials is described. The key step of this new synthetic approach involves the tetrabromomethane-promoted reaction between secondary amines, carbon disulfide and alkyl thiols under basic conditions at room temperature. New compounds from this series selected for anticancer screening showed selective sub-micromolar activity within BCA2-expressing human breast cancer cell lines.
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