Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.
Salemi, D., Cammarata, G., Agueli, C., Augugliaro, L., Corrado, C., Bica. MG, et al. (2015). miR-155 regulative network in FLT3 mutated acute myeloid leukemia. LEUKEMIA RESEARCH, 39(8), 883-896 [10.1016/j.leukres.2015.04.017].
miR-155 regulative network in FLT3 mutated acute myeloid leukemia
Salemi, Domenico;AGUELI, Cecilia;AUGUGLIARO, Luigi;CORRADO, Chiara;RAIMONDO, Stefania;ALESSANDRO, Riccardo;SANTORO, Alessandra
2015-01-01
Abstract
Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.
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