Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.

Salemi, D., Cammarata, G., Agueli, C., Augugliaro, L., Corrado, C., Bica. MG, et al. (2015). miR-155 regulative network in FLT3 mutated acute myeloid leukemia. LEUKEMIA RESEARCH, 39(8), 883-896 [10.1016/j.leukres.2015.04.017].

miR-155 regulative network in FLT3 mutated acute myeloid leukemia

Salemi, Domenico;AGUELI, Cecilia;AUGUGLIARO, Luigi;CORRADO, Chiara;RAIMONDO, Stefania;ALESSANDRO, Riccardo;SANTORO, Alessandra
2015

Abstract

Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.
http://www.sciencedirect.com/science/article/pii/S0145212615001289
Salemi, D., Cammarata, G., Agueli, C., Augugliaro, L., Corrado, C., Bica. MG, et al. (2015). miR-155 regulative network in FLT3 mutated acute myeloid leukemia. LEUKEMIA RESEARCH, 39(8), 883-896 [10.1016/j.leukres.2015.04.017].
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0145212615001289-main mir155.pdf

Solo gestori archvio

Dimensione 4.21 MB
Formato Adobe PDF
4.21 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/145096
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 18
social impact