Bisphosphonates are bone-turnover modulating drugs used to treat various diseases such as certain cancers, bone metastasis, bone- and calcium-related disorders, Paget`s disease, osteoporosis and osteopenia. Recently, several preliminary reports have reported the insurgence of osteonecrosis of the mandible and/or maxilla, associated with intravenously administered bisphosphonates. This case series describes the effects of bisphosphonates used in the treatment of certain cancers on oral bone tissues.
TORTORICI S, BURRUANO F, CARADONNA L, BUZZANCA ML AND DIFALCO P (2008). Maxillary bone necrosis following the use of bisphosphonates in patients with cancer: management and case series. RESEARCH JOURNAL OF BIOLOGICAL SCIENCES, 3(8), 925-929.
Maxillary bone necrosis following the use of bisphosphonates in patients with cancer: management and case series
TORTORICI, Silvia;BURRUANO, Francesco;CARADONNA, Luigi;
2008-01-01
Abstract
Bisphosphonates are bone-turnover modulating drugs used to treat various diseases such as certain cancers, bone metastasis, bone- and calcium-related disorders, Paget`s disease, osteoporosis and osteopenia. Recently, several preliminary reports have reported the insurgence of osteonecrosis of the mandible and/or maxilla, associated with intravenously administered bisphosphonates. This case series describes the effects of bisphosphonates used in the treatment of certain cancers on oral bone tissues.
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