Subjects with migraine are at increased risk of subcortical white matter lesions (WML). Reports of cognitive testing in adults with migraine have yielded inconsistent results. We performed a cross-sectional study to assess whether migraine without aura (MwA) is associated with impairment in executive functioning, a typical cognitive correlate of subcortical WML. Forty-five subjects with MwA and 90 controls, matched for age and education, underwent a cognitive battery of tests evaluating executive functions. The following migraine characteristics were collected: age at onset and length of migraine history, and frequency, duration and intensity of attacks. Subjects with MwA performed significantly lower than controls in tests evaluating complex, multifactorial executive functions. After multiple adjustments, the duration and intensity of migraine attacks significantly predicted cognitive disturbances. In the interictal phase of MwA there is evidence of mild executive dysfunction. The cumulative effects of repeated migraine attacks on prefronto-cerebellar loop probably account for our results.

CAMARDA C, MONASTERO R, PIPIA C, RECCA D, CAMARDA R (2007). Interictal executive dysfunction in migraineurs without aura: relationship with duration and intensity of attacks. CEPHALALGIA, 27(27), 1094-1100 [10.1111/j.1468-2982.2007.01394.x].

Interictal executive dysfunction in migraineurs without aura: relationship with duration and intensity of attacks.

CAMARDA, Cecilia
Writing – Original Draft Preparation
;
MONASTERO, Roberto
Supervision
;
PIPIA, Carmela;CAMARDA, Rosolino
2007

Abstract

Subjects with migraine are at increased risk of subcortical white matter lesions (WML). Reports of cognitive testing in adults with migraine have yielded inconsistent results. We performed a cross-sectional study to assess whether migraine without aura (MwA) is associated with impairment in executive functioning, a typical cognitive correlate of subcortical WML. Forty-five subjects with MwA and 90 controls, matched for age and education, underwent a cognitive battery of tests evaluating executive functions. The following migraine characteristics were collected: age at onset and length of migraine history, and frequency, duration and intensity of attacks. Subjects with MwA performed significantly lower than controls in tests evaluating complex, multifactorial executive functions. After multiple adjustments, the duration and intensity of migraine attacks significantly predicted cognitive disturbances. In the interictal phase of MwA there is evidence of mild executive dysfunction. The cumulative effects of repeated migraine attacks on prefronto-cerebellar loop probably account for our results.
Settore MED/26 - Neurologia
CAMARDA C, MONASTERO R, PIPIA C, RECCA D, CAMARDA R (2007). Interictal executive dysfunction in migraineurs without aura: relationship with duration and intensity of attacks. CEPHALALGIA, 27(27), 1094-1100 [10.1111/j.1468-2982.2007.01394.x].
File in questo prodotto:
File Dimensione Formato  
Camarda, Ex-Att migraine, Cephalalgia 2007.pdf

Solo gestori archvio

Dimensione 78.92 kB
Formato Adobe PDF
78.92 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/14287
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 55
social impact