This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and low solubility in water could give a very low parenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particular for intravenous administration.
|Data di pubblicazione:||2007|
|Titolo:||Nanostructured Lipid Carriers-Containing Anticancer Compounds: Preparation, Characterization, and Cytotoxycity Studies|
|Autori:||BONDI' ML; CRAPARO EF; GIAMMONA G; CERVELLO M; AZZOLINA A; DIANA P; MARTORANA A; CIRRINCIONE G|
|Autori interni:||DIANA, Patrizia|
CRAPARO, Emanuela Fabiola
|Tipologia:||Articolo su rivista|
|Citazione:||BONDI' ML, CRAPARO EF, GIAMMONA G, CERVELLO M, AZZOLINA A, DIANA P, et al. (2007). Nanostructured Lipid Carriers-Containing Anticancer Compounds: Preparation, Characterization, and Cytotoxycity Studies. DRUG DELIVERY, 14, 61-67.|
|Appare nelle tipologie:||01 - Articolo su rivista|
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